Independent evolution of monkeypox and variola viruses
نویسندگان
چکیده
منابع مشابه
Independent evolution of monkeypox and variola viruses.
Smallpox was eradicated more than 10 years ago, but infection with another Orthopoxvirus, monkeypox virus, can result in a clinical picture resembling smallpox. Human infection with monkeypox virus is extremely rare, not easily transmitted, and confined to the rain forest belt of Africa (Z. Jezek and F. Fenner, p. 81-102, in Human Monkeypox, 1988). Evidence that variola virus, the causative age...
متن کاملThe highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon
Variola virus (VARV) caused smallpox, one of the most devastating human diseases and the first to be eradicated, but its deliberate release represents a dangerous threat. Virulent orthopoxviruses infecting humans, such as monkeypox virus (MPXV), could fill the niche left by smallpox eradication and the cessation of vaccination. However, immunomodulatory activities and virulence determinants of ...
متن کاملA tale of two clades: monkeypox viruses.
Human monkeypox was first recognized outside Africa in 2003 during an outbreak in the USA that was traced to imported monkeypox virus (MPXV)-infected West African rodents. Unlike the smallpox-like disease described in the Democratic Republic of the Congo (DRC; a Congo Basin country), disease in the USA appeared milder. Here, analyses compared clinical, laboratory and epidemiological features of...
متن کاملHybrids Derived from the Viruses of Variola Major and Cowpox.
The isolation of presumptive hybrids from the viruses of variola major and cowpox has already been described (Dumbell & Bedson, 1964). We report here the detailed characterization of the 16 clones of virus obtained. As with the alastrimrabbit pox hybrids considered in the previous paper (Bedson & Dumbell, 1964), attention has been paid to the behaviour of the ceiling temperature character in re...
متن کاملMonkeypox and whitepox viruses in West and Central Africa.
Prospects for the eradication of smallpox are now highly encouraging. With the cessation of man-to-man transmission, the question of possible animal reservoirs of smallpox becomes increasingly important. During the period 1970-1975, 20 cases of a smallpox-like disease were detected in smallpox-free areas of tropical rain forest in West and Central Africa. Epidemiological and virological investi...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1992
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.66.12.7565-7567.1992